Parkinson disease

Since I began to study pharmacology in my last career, the central nervious system imppasioned me. Of course, this passion isn´t about the biology involved in, instead, is about the biochemistry involved in celular process and how it impacts over the character, behavior and health of people; a good example can be the neurotransmission disruption on substantia nigra.

The parkinson´s disease is a degenerative and progressive disorder that affects nerve cells in the basal ganglia and the substantia nigra, at the central nervious system. At the susbtantia nigra neurotransmission, nerve cells produce and free dopamine, a neurotransmitter asociated with the plan and control body movement.

When dopamine producing nerve cells die off, up to a rate of 80%, symptoms such as tremor, slowness of movemente, stiffness, balance problems and other symptoms appear. This symptoms are a fundamental consecuence of a not regulated activity of acethylcoline producing nerve cells from thalamus (in minor grade from glutamate producing nerve cells from cortex), and impacts directly in the quality of life.

Although we still do not have a cure, but with some palliative drugs that delay the progression of the disease, such as the famous Levodopa, however, it is far from the best treatment and its use is delayed by the earlyresistance generate for it.